Layouts are taken here literally as rhythms. Modular grid layouts can be filled analogously to a sequencer. Placing a headline, text, image, or whitespace produces a corresponding drum sound. In this way, the layout can be experienced with both eyes and ears. Try it out and see the code at editor.p5js.org
This is also a playful way to obtain data to train an artificial neural networks (it is a pattern in data finder) that generates new, preferred layouts:
For more background also check: Research on spatial arrangement or composition or layout